How to make an SSRS preview match the publishted report?

The preview of the SSRS report looks great and everything lines up. There are four charts arranged in 2 by 2 and alongside of that on the right is a textbox and a rectangle below it with a table in it. But when I go live, with the RDL file, there is a huge gap between the textbox and the rectangle with the list in it. How do I align it? This must be a problem others have overcome. And this is not the first time I have seen align completely different from preview mode VS the published RDL. Does it have something to do with the fact that it is compiled for a 2008 Report Server?