Try the syntax of DATEDIFF(ss, SELECT MAX(startDate) FROM myTable, SELECT MAX(EndDate) FROM myTable).
It comes from this source: DateDiff to the second
The original expression that you posted should work if your dates are being interpreted as MM/DD/YYYY. I created a test report using your expressions, and it does work. See screenshots below. So if it does not work for you, there is something else that is in play here. One possibility is that the dates are being interpreted as DD/MM/YYYY, in which case 11/2/2015 would be interpreted as February 11th and 11/3/2015 would be March 11.
It is probably something very specific to your data or environment that you would have to debug. Start with the simple example that I posted - i.e., two text boxes with the dates you want and a third one with the expression.
In your expression you have something like this: DateDiff("h", Fields!PROSPECT_ADMIT_DATE.Value,ReportItems!Textbox11.Value)
That looks like you are taking the difference between the data from a dataset for the second parameter and the data from a TextBox for the third parameter. That does not sound right based on the screenshot you posted. Look at what TextBox11 is using the properties dropdown menu and selecting TextBox1. I would have thought that your expression should be something like
TextBox11 isn't a dataset field..
That could be the reason its taking the quickest time
=IIf(ISNOTHING(Fields!MSS_DATE.Value),ReportItems!RN_DATE_TIME.Value,
IIf(ReportItems!RN_DATE_TIME.Value= ReportItems!MSS_DATE_TIME.Value,ReportItems!RN_DATE_TIME.Value,
IIf(ReportItems!RN_DATE_TIME.Value < ReportItems!MSS_DATE_TIME.Value, ReportItems!RN_DATE_TIME.Value,ReportItems!MSS_DATE_TIME.Value)))
Maybe I would need to incorporate this somehow into the first expression I posted so that it would take Dataset data...
Ive' tried a switch statement but with no success going to attempt other methods...
-- update I successfully combined both statements with no end results
My belief is that its within the date/time itself on how its formatted...